Food analysis has been expanded to incorporate all manner of post-genomic profiling, classification, nontargeted screening, and authentication of any of a variety of food, environmental, or agricultural products. We will demonstrate workflows utilizing SCIEX high resolution mass spectrometric technology, novel data acquisition techniques, spectral libraries, and software tools to utilize nontargeted and statistical approaches to classify such samples as juices, herbs, and cannabis strains, and identify unknown constituents in complex matrices like citrus fruits extracts and even environmental water samples.